To evaluate the capability of cleaning agents to degrade established biofilms in microgravity.
Biofilms are complex multicellular networks, typically developing on surfaces and composed of a mixture of cells and an extracellular matrix that offers significant protection from antimicrobial agents. While these present a significant medical problem on Earth, they are also found aboard the International Space Station, where they pose a risk to astronauts and often require time-consuming cleaning procedures to remove. Students at Mission Discovery Newcastle 2021 proposed a study investigating new, time effective methods to break down established biofilms in microgravity. While the students aimed for this research to identify a way to speed up cleaning protocols, increasing the understanding of biofilm degradation mechanics in microgravity will shed light on the mechanics of biofilm regulation with several potential Earth-based benefits
Beginning January 2022, this experiment has entered enter primary development within the Schnell lab at the Department of Biochemistry. The first research effort will begin with the establishment of biofilm positive cultures, which will be grown to dominate growth plates and then screened against various antimicrobial agents. Utilising the unique 'Flexilid' technique, pioneered by ISSET and King's College London in 2013 in order to investigate antimicrobial activity in microgravity within NASA safety limitations. we will assess the student proposed antimicrobial agents to assess their stability and functionality ready for eventual launch to the ISS in 2023.
